GENENTECH PROPOSED ACTIONS
General Plan Amendment
Zoning Map Amendments
Master Plan Amendment
Street Vacation Findings of Conformance
Presented to City of South San Francisco City Council
June 25, 2025
Government Code Section 54957.5
SB 343 Item #8
06/25/2025 REG CC
2 50 YEARS OF GENENTECH
Genentech Proposed Actions
“It’s still amazing to think that on the very site where Bethlehem Steel stood, Genentech stands today. South San Francisco built the steel for the BART tunnel, the wire rope for the Golden Gate Bridge. We built Liberty Ships. And when that steel industry died, the city didn’t suffer the same fate as other steel mill towns, because the biotech industry established itself here.”
- Former SSF City Manager Mike Futrell
3 4.9m sq ft
2019 Build-Out
(Owned sq ft)
Growth Cap in 2007
Master Plan
2020 Master
Plan Allowance
6.8m sq ft
9.0m sq ft
• Master Plan approved by South San Francisco
City Council in 2020
• Secures Genentech’s ability to operate and
grow in the face of increasing development
pressure in Oyster Point
• Allows maximum size of campus to increase to
9M square feet in long-term
• Not a guarantee of development or headcount
growth but allows Genentech to respond
quickly and flexibly to meet business needs
• Highlights Genentech’s commitment to
environmentally-sustainable growth in the
South San Francisco community
Genentech Proposed Actions
GENENTECH MASTER PLAN
44 PROJECT OVERVIEW
Genentech Proposed Actions
General Plan Amendment
Transportation → Business Technology Park Point San
Bruno Blvd.
Zoning Map Amendment Street Vacations
(No Physical Changes, Ownership Only)
BTP-M → GMPD Cabot Rd. DNA Wy.
5 STREET VACATION - BENEFITS TO GENENTECH
Genentech Proposed Actions
Facilitates a future pedestrian-oriented
and vehicle-deprioritized campus, as
envisioned by the Master Plan
Lays the groundwork for major
investments that will deliver better
science in shorter time frames
Improves aging infrastructure through
sustainable purpose-built development
Fulfills the Master Plan mandatory
rezoning requirement
6 STREET VACATION - BENEFITS TO SOUTH SAN FRANCISCO
Genentech Proposed Actions
Unlocks investment for future
development in South San Francisco
Provides unrestricted funds through the
transaction to address City priorities
Eliminates City maintenance obligations
for roads that predominantly serve
Genentech
Implements the Master Plan through
pedestrian-focused infill development
and high-quality campus open spaces
Creates union jobs and increases
tax revenue
7 PROJECT COMMITMENTS
All public destinations remain accessible even with
roadway ownership change
Access to Bay Trail and Wind Harp will remain
unchanged and are accessible via publicly
accessible roadways and signed, flat routes for
cyclists and pedestrians
Improved wayfinding signage to help visitors access
public destinations (Bay Trail, Wind Harp Park, and
other future amenities)
Emergency access will be preserved through close
partnership with Police and Fire departments
No increase to campus buildout potential beyond
approved Master Plan
Genentech Proposed Actions
8 PUBLIC DESTINATIONS AND BICYCLE ACCESS
Genentech Proposed Actions
P
P
P
E GRAND AVE
P
DNA WAY
CABOT RD
ALLERTON AVE
Bay Trail
Wind
Harp
Park PT SAN
BRUNO BLVD
DNA WAY
FORBES BLVD
DNA WAY
P
Legend
Bay Trail
Bicycle Route
Bicycle access along hilly
DNA Way to be eliminated
through Genentech campus.
However, the number and
location of bicycle access
points to Bay Trail and Wind
Harp will remain unchanged
and are accessible via
signed, flat routes.
Public Park
(future)
To Ferry/
Marina Bay Trail
Point
San Bruno
9 VEHICLE ACCESS
Genentech Proposed Actions
E. Grand Ave
17,000 vehicles
CABOT RD
ALLERTON AVE
Point San Bruno Blvd.
2,600 vehicles
95% start/end on campus
Forbes Blvd.
6,000 vehicles Future physical street
modifications will require
City review
Potential street closures are
consistent with the
Genentech Master Plan and
will enable future
pedestrian-oriented
campus improvements
Bicycle access and Bay Trail
Access will be enhanced and
preserved along flat routes
with upgraded signage
Negligible impact to
adjacent streets
Point
Wind San Bruno
Harp
Park
Public Park
(future)
DNA Way
3,500 vehicles
95% start/end on campus
Average total
vehicles per
weekday
P
P
P
P
P
Genentech Proposed Actions 10
EMERGENCY ACCESS
Building 38, Genentech Emergency Operations Center
• Genentech is committed to ongoing
close coordination with public
safety officials
• Emergency access routes will be maintained
throughout all project phases
• No immediate road closures are proposed
• Any future modifications to emergency
access will require city agency review
and approval
• Preliminary and ongoing discussions held
with Fire and Police departments
1111
PROPOSED GENERAL PLAN AMENDMENT
Genentech Proposed Actions
Current
Transportation
Proposed
Business Technology Park
Genentech maintains and owns E. Grand Ave. within campus boundary 1212
PROPOSED ZONING MAP AMENDMENTS
Genentech Proposed Actions
Current
BTP-M
Proposed
GMPD
333 Point San
Bruno Blvd.
383-393 E.
Grand Ave.
525 DNA
Wy.
Genentech maintains and owns E. Grand Ave. within campus boundary 1313
STREET VACATION
Genentech Planning Amendments Proposal
Forbes Blvd
Allerton Ave
E Grand Ave
Point San
Bruno Blvd.
Cabot Rd. DNA Wy.
Genentech Proposed Actions
• Proposed City vacation of three public
street segments and associated 10-foot
public utility easements
• Consistent with General Plan policies to
prioritize pedestrian connections:
“Accessibility, connectivity, and the quality
of the pedestrian environment are
important characteristics of community
design.” (SSF General Plan, Community
Design)
• On May 15, 2025 the Planning Commission
adopted Resolution 25-396 determining
that the proposed street vacations conform
to the SSF General Plan
1414
Questions and Comments